In order to better exert the monitoring and early warning application potential of satellitetoground lightning detection data in the Mesoscale Convective System (MCS), this study takes an MCS in Shandong on June 27, 2018, as a case, using the cloud top temperature, cooling rate, the reflectivity from radar and the satellite-to-ground lightning data from FY-4A Lightning Mapping Imager (LMI) and Advanced TOA and Direction system (ADTD) to analyze the lightning distribution characteristics and its relationship with the evolution of convection. The results show a good consistence of the satellite-to-ground lightning data. The lighting of LMI was further located in front of the convective cloud and had a high agreement with the precipitation region. In the early development stage of MSC, LMI detected lightning earlier than ADTD, and the lightning was located in the centre and the front side of the radar echo. The vertical section of the echo showed a forward tilting, which was a good indicator of the movement and evolution trend of convection. Thus, the location of the lightning from LMI could be used to assist in the forecast of strong convection areas. In the mature stage, the frequency of satellite-to-ground lightning increased, and the proportion of positive ground lightning was relatively large. Hail disasters occurred in many places in Shandong Province during this period. The LMI mostly appeared in the weak or no-echo area in front of the moving direction of the convective system, while the ADTD lightning was closer to the centre position of the echo. During the merging stage, some of the LMI lightning was located at the backside of the front, strong echo area corresponding to the strong echo area.