A cloud particle measurement system is a key instrument to carry out the research on cloud precipitation physics and weather modification. In China, most of the instruments are currently imported from overseas. Not only the calibration of the instrument depends on the manufacturers abroad, and costs users’ large amount of money and time, but also the traditional glass bead calibration method has defects of easy adhesion and so on. Based on the present situation, a new calibration method is proposed, which utilizes the sophisticated inkjet printing technology and visual measurement techniques to produce controllable, stable continuous water droplets of 5 diameters (from 10 μm to 50 μm) for the calibration of the instruments. The prototype structure of the system is described in detail. The factors affecting the working performance of the system are analyzed. The same Cloud Droplet Probe (CDP) is calibrated, and the new method is compared with the traditional method. The results show that the method can meet the needs of calibration of the cloud particle measurement system, and the equipment performs well and is easy to control.